The cutting-edge science behind genoSCORE-ACT. 

  • genoSCORE-ACT assesses an individual’s genetic risk for the future development of Late-Onset Alzheimer’s disease.

  • Our test evaluates your genetic makeup from your DNA, which is extracted from the saliva sample you send to our laboratory.

  • Our test assesses over 112,000 genetic markers in your DNA to compute a personal risk score.

  • Each stage in the process is meticulously carried out by trained technicians in a world-class laboratory in Manchester.

  • Our test is 80.2%* accurate in predicting your personal risk score for Alzheimer’s disease.

  • We take data protection seriously. All tests are carried out confidentially and we will never share your information with third parties.

Want to learn more about the science behind genoSCORE-ACT?

How does the test work?

The test evaluates your genetic makeup from your DNA, which is extracted from the saliva sample you send to our laboratory. Scientists have discovered that your predisposition, or your chance of developing some medical conditions is also due, in part, to your genetics. Researchers looking at the genetics of Alzheimer’s disease have identified over 112,000 genetic variations that are associated with the condition. Some make the chances of developing Alzheimer’s disease more likely, while others are known to be protective.

Our scientists analyse your DNA to check which genetic variations you have, and using our unique evaluation algorithm compute your personal risk score. Your personal risk score indicates your lifetime risk of developing Late-Onset Alzheimer’s disease (LOAD) when compared to the population. This means you’ll know whether you are at more or less risk than other people. The process of extracting your DNA from saliva and then carrying out the complex genetic evaluation takes our scientists several weeks to complete.

Understanding your genetic risk

Genetic risk is your chance of inheriting a disorder or disease. There are many genetic variations that contribute to the development of Alzheimer’s disease. Your personal risk score is therefore an estimate, and importantly, it is based on the unique genetic mixture you inherited from your mother and father. 

The risk score indicates your chance or likelihood of developing Alzheimer’s disease during your lifetime. It is not a diagnosis, nor is it certain that someone with a high risk score will go on to develop the condition. This is because your overall risk is also affected by other things, such as your lifestyle (e.g., drinking, smoking, being overweight) and other health issues (e.g., whether you have diabetes, depression, hypertension, etc.)

*P. Daunt, C. G. Ballard, B. Creese, G. Davidson, J. Hardy, O. Oshota, R. J. Pither, A.M. Gibson & for the Alzheimer’s Disease Neuroimaging Initiative, 2020. Polygenic Risk Scoring is an Effective Approach to Predict Those Individuals Most Likely to Decline Cognitively Due to Alzheimer’s Disease, J Prev Alzheimers Disease. Source